Abstract Background Treacher Collins syndrome (TCS) is an autosomal dominant craniofacial disorder caused by frameshift deletions or duplications in the TCOF1 gene.These mutations cause premature termination codons, which are predicted to lead to mRNA degradation by nonsense mediated mRNA decay (NMD).Haploinsufficiency of the gene product (treacle)
IntroductionThe AB-type toxin AIP56 is a key virulence factor of Photobacterium damselae subsp.piscicida (Phdp), inducing apoptosis in fish immune cells.The discovery of AIP56-like and AIP56-related toxins in diverse organisms, including human-associated Vibrio strains, highlights the evolutionary conservation of this toxin family, suggesting that
The mechanism(s) by which neonates testing positive for coronavirus disease 2019 (COVID-19) acquire their infection has been largely unknown.Transmission of the etiological agent, SARS-CoV-2, from mother to infant has been suspected but has been difficult to confirm.This communication summarizes the spectrum of pathology findings from pregnant wome
Age-related hearing loss affects a significant proportion of adults aged 60 years and above, with a prevalence of 65%.This condition has a negative impact on both physical and mental well-being, and while hearing interventions can Demi Permanent help alleviate the effects of hearing loss, they cannot completely restore normal hearing or halt the pr
G-protein-coupled receptors (GPCRs) play a crucial role in the gene regulation of processes related to the response to different types of stress in fungi.These receptors act as sensors of extracellular signals and transmit the information Shipping Cost to the interior of the cell through G-proteins.In the presence of different and specific types of